Bioinformatics analysis of laryngeal squamous cell carcinoma: seeking key candidate genes and pathways.

ABSTRACT:

Background

Laryngeal squamous cell carcinoma (LSCC) is the second most aggressive head and neck squamous cell carcinoma. Although much work has been done to optimize its treatment, patients with LSCC still have poor prognosis. Therefore, figuring out differentially expressed genes (DEGs) contained in the progression of LSCC and employing them as potential therapeutic targets or biomarkers for LSCC is extremely meaningful.

Methods

Overlapping DEGs were screened from two standalone Gene Expression Omnibus datasets, and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were performed. By applying STRING and Cytoscape, a protein-protein network was built, and module analysis was carried out. The hub genes were selected by maximal clique centra

SUBMITTER: Ma J 

PROVIDER: S-EPMC8052978 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature