Initiation, Continuation, Switching, and Withdrawal of Heart Failure Medical Therapies During Hospitalization.

ABSTRACT: Patients with worsening heart failure with reduced ejection fraction (HFrEF) spend a large proportion of time in the hospital and other health care facilities. The benefits of guideline-directed medical therapy (GDMT) in the outpatient setting have been shown in large randomized controlled trials. However, the decision to initiate, continue, switch, or withdraw HFrEF medications in the inpatient setting is often based on multiple factors and subject to significant variability across providers. Based on available data, in well-selected, treatment-naïve patients who are hemodynamically stable and clinically euvolemic after stabilization during hospitalization for HF, elements of GDMT can be safely initiated. Inpatient continuation of GDMT for HFrEF appears safe and well-tolerated in most hem

SUBMITTER: Bhagat AA 

PROVIDER: S-EPMC8053043 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature