Biological relevance and therapeutic potential of G-quadruplex structures in the human noncoding transcriptome.

ABSTRACT: Noncoding RNAs are functional transcripts that are not translated into proteins. They represent the largest portion of the human transcriptome and have been shown to regulate gene expression networks in both physiological and pathological cell conditions. Research in this field has made remarkable progress in the comprehension of how aberrations in noncoding RNA drive relevant disease-associated phenotypes; however, the biological role and mechanism of action of several noncoding RNAs still need full understanding. Besides fulfilling its function through sequence-based mechanisms, RNA can form complex secondary and tertiary structures which allow non-canonical interactions with proteins and/or other nucleic acids. In this context, the presence of G-quadruplexes in microRNAs and long noncod

SUBMITTER: Tassinari M 

PROVIDER: S-EPMC8053107 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature