Mendelian randomization integrating GWAS and eQTL data revealed genes pleiotropically associated with major depressive disorder.

ABSTRACT: Previous genome-wide association studies (GWAS) have identified potential genetic variants associated with the risk of major depressive disorder (MDD), but the underlying biological interpretation remains largely unknown. We aimed to prioritize genes that were pleiotropically or potentially causally associated with MDD. We applied the summary data-based Mendelian randomization (SMR) method integrating GWAS and gene expression quantitative trait loci (eQTL) data in 13 brain regions to identify genes that were pleiotropically associated with MDD. In addition, we repeated the analysis by using the meta-analyzed version of the eQTL summary data in the brain (brain-eMeta). We identified multiple significant genes across different brain regions that may be involved in the pathogenesis of MDD. Th

SUBMITTER: Yang H 

PROVIDER: S-EPMC8053199 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature