Preliminary evidence of effects of potassium chloride on a metabolomic path to diabetes and cardiovascular disease.

ABSTRACT:

Introduction

Low potassium intake can affect cardiovascular disease (CVD) risk and cardiometabolic risk factors.

Objective

We hypothesize that potassium chloride (KCl) supplementation can improve cardiovascular risk metabolomic profile.

Methods

In this secondary analysis of a pilot randomized clinical trial (RCT) of 26 participants with prediabetes randomized to KCl or placebo, we performed targeted mass-spectrometry-based metabolomic profiling on baseline and 12-week (end-of-study) plasma samples. Principal component analysis (PCA) was used to reduce the many correlated metabolites into fewer, independent factors that retain most of the information in the original data.

Results

Those taking KCl had significant reductions (corresponding to lower cardiovascular

SUBMITTER: Chatterjee R 

PROVIDER: S-EPMC8053254 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature