Association between menopausal hormone therapy, mammographic density and breast cancer risk: results from the E3N cohort study.

ABSTRACT:

Background

Menopausal hormone therapy (MHT) is a risk factor for breast cancer (BC). Evidence suggests that its effect on BC risk could be partly mediated by mammographic density. The aim of this study was to investigate the relationship between MHT, mammographic density and BC risk using data from a prospective study.

Methods

We used data from a case-control study nested within the French cohort E3N including 453 cases and 453 matched controls. Measures of mammographic density, history of MHT use during follow-up and information on potential confounders were available for all women. The association between MHT and mammographic density was evaluated by linear regression models. We applied mediation modelling techniques to estimate, under the hypothesis of a causal model, the

SUBMITTER: Fornili M 

PROVIDER: S-EPMC8053286 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature