Vitamin K antagonist anticoagulant usage is associated with increased incidence and progression of osteoarthritis.

ABSTRACT:

Objectives

Vitamin K is hypothesised to play a role in osteoarthritis (OA) pathogenesis through effects on vitamin K-dependent bone and cartilage proteins, and therefore may represent a modifiable risk factor. A genetic variant in a vitamin K-dependent protein that is an essential inhibitor for cartilage calcification, matrix Gla protein (MGP), was associated with an increased risk for OA. Vitamin K antagonist anticoagulants (VKAs), such as warfarin and acenocoumarol, act as anticoagulants through inhibition of vitamin K-dependent blood coagulation proteins. VKAs likely also affect the functioning of other vitamin K-dependent proteins such as MGP.

Methods

We investigated the effect of acenocoumarol usage on progression and incidence of radiographic OA in 3494 participants of

SUBMITTER: Boer CG 

PROVIDER: S-EPMC8053344 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature