Dataset Information

Effect of Ammonium Chloride in addition to standard of care in outpatients and hospitalized COVID-19 patients: A randomized clinical trial.

ABSTRACT:

Objective

The COVID-19 pandemic has called an urgent need for drug repurposing to improve the outcome of the disease. Quaternary ammonium compounds have been demonstrated to have antiviral effects and may be of use against SARS-CoV-2 infections.

Design

In this double-blind, single-center study, we enrolled patients with positive PCR test and/or CT findings for COVID-19. The participants of each group were randomly assigned to Diphenhydramine Compound (Diphenhydramine + Ammonium Chloride) plus standard of care or to Diphenhydramine alone and standard of care groups. The primary outcome was all-cause mortality within 30 days of randomization. Secondary outcomes include viral burden, clinical status, assessed by a 5-point ordinal scale, and length of stay in hospitalized patients.

Results

A total of 120 patients were included in the trial, 60 of which were assigned to the Ammonium Chloride group. The primary endpoint was not statistically different between the two groups (HR: 3.02 (95% CI, 0.57-16.06; p = 0.195)). Recovery time and viral burden were significantly lower in the Ammonium Chloride group, corresponding to an odds ratios of 1.8 (95% CI, 1.15-2.83; p = 0.01) and 7.90 (95% CI, 1.62-14.17; p = 0.014), respectively.

Conclusion

The findings of this study advocate the careful addition of Ammonium Chloride to standard of care for COVID-19 patients.

SUBMITTER: Siami Z

PROVIDER: S-EPMC8053358 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

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Publications

Effect of Ammonium Chloride in addition to standard of care in outpatients and hospitalized COVID-19 patients: A randomized clinical trial.

Siami Zeinab Z Aghajanian Sepehr S Mansouri Somayeh S Mokhames Zakiye Z Pakzad Reza R Kabir Kourosh K Norouzi Mehdi M Soleimani Alireza A Hedayat Yaghoobi Mojtaba M Shadabi Shahrzad S Tajbakhsh Ramin R Kargar Kheirabad Ali A Mozhgani Sayed-Hamidreza SH

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20210418

<h4>Objective</h4>The COVID-19 pandemic has called an urgent need for drug repurposing to improve the outcome of the disease. Quaternary ammonium compounds have been demonstrated to have antiviral effects and may be of use against SARS-CoV-2 infections.<h4>Design</h4>In this double-blind, single-center study, we enrolled patients with positive PCR test and/or CT findings for COVID-19. The participants of each group were randomly assigned to Diphenhydramine Compound (Diphenhydramine + Ammonium Ch ...[more]

PMID: 33878462

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Dataset Information

Effect of Ammonium Chloride in addition to standard of care in outpatients and hospitalized COVID-19 patients: A randomized clinical trial.

Objective

Design

Results

Conclusion

Publications

Effect of Ammonium Chloride in addition to standard of care in outpatients and hospitalized COVID-19 patients: A randomized clinical trial.

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