Clinical and Genetic Features of Brainstem Glioma in Adults: A Report of 50 Cases in a Single Center.

ABSTRACT:

Background and purpose

Brainstem gliomas (BSGs) in adults are rare brain tumors with dismal outcomes. The aim of this study was to determine the clinical and genetic features in a series of BSGs and their association with the prognosis.

Methods

Fifty patients who underwent a stereotactic biopsy between January 2016 and April 2018 at a single institution were collected. Data on clinicopathological characteristics were analyzed and factors associated with patient survival were identified using a Cox regression model.

Results

The median age at diagnosis was 55.5 years, and 62% of the patients were male. Glioblastoma (44%) accounted for the largest proportion of BSGs, and oligodendroglioma (2 of 50) was rarely encountered. The IDH mutation (6 of 44) occurred infreq

SUBMITTER: Zhou C 

PROVIDER: S-EPMC8053546 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature