Extracerebellar Signs and Symptoms in 117 Korean Patients with Early-Stage Spinocerebellar Ataxia.

ABSTRACT:

Background and purpose

Spinocerebellar ataxias (SCAs) are the most common form of hereditary ataxias. Extracerebellar signs have been well described and are helpful in differentiating the SCA subtypes. However, there are few reports on the early-stage extracerebellar signs in various SCA subtypes. This study explored the clinical and magnetic resonance imaging (MRI) characteristics of early-stage SCAs in the Korean population.

Methods

We retrospectively reviewed the medical records of genetically confirmed SCA patients with a disease duration of <5 years. Data on baseline characteristics, extracerebellar signs, and initial MRI findings were organized based on SCA subtypes.

Results

This study included 117 SCA patients with a median age at onset of 40.6 years. The famil

SUBMITTER: Kim M 

PROVIDER: S-EPMC8053557 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature