Age-dependency of terminal ileum tissue resident memory T cell responsiveness profiles to S. Typhi following oral Ty21a immunization in humans.

ABSTRACT:

Background

The impact of aging on the immune system is unequivocal and results in an altered immune status termed immunosenescence. In humans, the mechanisms of immunosenescence have been examined almost exclusively in blood. However, most immune cells are present in tissue compartments and exhibit differential cell (e.g., memory T cells -T_M) subset distributions. Thus, it is crucial to understand immunosenescence in tissues, especially those that are exposed to pathogens (e.g., intestine). Using a human model of oral live attenuated typhoid vaccine, Ty21a, we investigated the effect of aging on terminal ileum (TI) tissue resident memory T (T_RM) cells. T_RM provide immediate adaptive effector immune responsiveness at the infection site. However, it i

SUBMITTER: Booth JS 

PROVIDER: S-EPMC8053564 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature