Prostate Stereotactic Body Radiation Therapy: An Overview of Toxicity and Dose Response.

ABSTRACT:

Purpose

Ultrahypofractionationed radiation therapy for prostate cancer is increasingly studied and adopted. The American Association of Physicists in Medicine Working Group on Biological Effects of Hypofractionated Radiotherapy therefore aimed to review studies examining toxicity and quality of life after stereotactic body radiation therapy (SBRT) for prostate cancer and model its effect.

Methods and materials

We performed a systematic PubMed search of prostate SBRT studies published between 2001 and 2018. Those that analyzed factors associated with late urinary, bowel, or sexual toxicity and/or quality of life were included and reviewed. Normal tissue complication probability modelling was performed on studies that contained detailed dose/volume and outcome data.

Results

SUBMITTER: Wang K 

PROVIDER: S-EPMC8053668 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature