Cystic fibrosis airway microbiota associated with outcomes of nontuberculous mycobacterial infection.

ABSTRACT:

Rationale

Pulmonary infections with nontuberculous mycobacteria (NTM) are increasingly prevalent in people with cystic fibrosis (CF). Clinical outcomes following NTM acquisition are highly variable, ranging from transient self-resolving infection to NTM pulmonary disease associated with significant morbidity. Relationships between airway microbiota and variability of NTM outcomes in CF are unclear.

Objective

To identify features of CF airway microbiota associated with outcomes of NTM infection.

Methods

188 sputum samples, obtained from 24 subjects with CF, each with three or more samples collected from 3.5 years prior to, and up to 6 months following incident NTM infection, were selected from a sample repository. Sputum DNA underwent bacterial 16S rRNA gene sequencing

SUBMITTER: Caverly LJ 

PROVIDER: S-EPMC8053818 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature