New pathway ameliorating ulcerative colitis: focus on Roseburia intestinalis and the gut-brain axis.

ABSTRACT:

Background

The community of gut microbes is a key factor controlling the intestinal barrier that communicates with the nervous system through the gut-brain axis. Based on our clinical data showing that populations of Roseburia intestinalis are dramatically decreased in the gut of patients with ulcerative colitis, we studied the efficacy of a strain belonging to this species in the context of colitis and stress using animal models.

Methods

Dextran sulfate sodium was used to induce colitis in rats, which then underwent an enema with R. intestinalis as a treatment. The disease activity index, fecal changes and body weight of rats were recorded to evaluate colitis, while histological and immunohistochemical analyses were carried out to examine colon function, and 1

SUBMITTER: Xu F 

PROVIDER: S-EPMC8053823 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature