Potentially inappropriate proton-pump inhibitor prescription in the general population: a claims-based retrospective time trend analysis.

ABSTRACT:

Background

Proton-pump inhibitors (PPI) are among the most prescribed drugs worldwide, and a large body of evidence raises concerns about their inappropriate use. Previous estimates of inappropriate use varied due to different definitions and study populations.

Aims

We aimed to measure the population-based incidence and time trends of PPI and potentially inappropriate PPI prescriptions (PIPPI) with a novel method, continuously assessing excessive cumulative doses based on clinical practice guidelines. We also assessed association of patient characteristics with PPI prescriptions and PIPPI.

Methods

This was an observational study based on a large insurance claims database of persons aged >18 years with continuous claims records of ⩾12 months. The observation period was

SUBMITTER: Muheim L 

PROVIDER: S-EPMC8053831 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature