Cytokinetic abscission is part of the midblastula transition in early zebrafish embryogenesis.

ABSTRACT: Animal cytokinesis ends with the formation of a thin intercellular membrane bridge that connects the two newly formed sibling cells, which is ultimately resolved by abscission. While mitosis is completed within 15 min, the intercellular bridge can persist for hours, maintaining a physical connection between sibling cells and allowing exchange of cytosolic components. Although cell-cell communication is fundamental for development, the role of intercellular bridges during embryogenesis has not been fully elucidated. In this work, we characterized the spatiotemporal characteristics of the intercellular bridge during early zebrafish development. We found that abscission is delayed during the rapid division cycles that occur in the early embryo, giving rise to the formation of interconnected c

SUBMITTER: Adar-Levor S 

PROVIDER: S-EPMC8053991 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature