Immune cells fold and damage fungal hyphae.
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ABSTRACT:
SUBMITTER: Bain JM
PROVIDER: S-EPMC8053999 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Publications
Immune cells fold and damage fungal hyphae.
Bain Judith M JM Alonso M Fernanda MF Childers Delma S DS Walls Catriona A CA Mackenzie Kevin K Pradhan Arnab A Lewis Leanne E LE Louw Johanna J Avelar Gabriela M GM Larcombe Daniel E DE Netea Mihai G MG Gow Neil A R NAR Brown Gordon D GD Erwig Lars P LP Brown Alistair J P AJP
Proceedings of the National Academy of Sciences of the United States of America 20210401 15
Innate immunity provides essential protection against life-threatening fungal infections. However, the outcomes of individual skirmishes between immune cells and fungal pathogens are not a foregone conclusion because some pathogens have evolved mechanisms to evade phagocytic recognition, engulfment, and killing. For example, <i>Candida albicans</i> can escape phagocytosis by activating cellular morphogenesis to form lengthy hyphae that are challenging to engulf. Through live imaging of <i>C. alb ...[more]
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