Atmospheric pressure chemical ionisation mass spectrometry for the routine analysis of low molecular weight analytes.

ABSTRACT: The routine analysis of low molecular weight analytes by mass spectrometry is often complicated by the lability of the analyte's functional groups and/or the lack of moieties that can be easily charged. If a molecule is too labile this precludes analysis by techniques such as electron ionisation or chemical ionisation as the analyte will undergo thermal decomposition prior to ionisation as well as spontaneous fragmentation during the ionisation process. If the analyte has a low propensity to form ions in electrospray ionisation (i.e., lacks acidic or basic sites) then often no analyte related ions are observed. In this paper, the robustness and versatility of the established method of atmospheric pressure chemical ionisation is demonstrated for the analysis of low molecular weight analytes

SUBMITTER: Gates PJ 

PROVIDER: S-EPMC8054169 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature