Meta-analysis reveals significant association between FOXP3 polymorphisms and susceptibility to Graves' disease.

ABSTRACT:

Objective

This meta-analysis aimed to determine the associations between the rs3761547, rs3761548, and rs3761549 single-nucleotide polymorphisms (SNPs) of the forkhead box P3 (FOXP3) gene and susceptibility to Graves' disease (GD).

Methods

Case-control studies with information on the associations between the rs3761547, rs3761548, and rs3761549 FOXP3 SNPs and GD published before 01 May 2020 were identified in the PubMed, Embase, Web of Science, and China National Knowledge Infrastructure databases. Data from the studies were analyzed using RevMan version 5.3.

Results

Seven independent case-control studies including 4051 GD patients and 4569 controls were included in the meta-analysis. The overall pooled analysis indicated that FOXP3/rs3761548 and <

SUBMITTER: Tan G 

PROVIDER: S-EPMC8054215 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature