The methodological quality of individual participant data meta-analysis on intervention effects: systematic review.

ABSTRACT:

Objective

To assess the methodological quality of individual participant data (IPD) meta-analysis and to identify areas for improvement.

Design

Systematic review.

Data sources

Medline, Embase, and Cochrane Database of Systematic Reviews.

Eligibility criteria for selecting studies

Systematic reviews with IPD meta-analyses of randomised controlled trials on intervention effects published in English.

Results

323 IPD meta-analyses covering 21 clinical areas and published between 1991 and 2019 were included: 270 (84%) were non-Cochrane reviews and 269 (84%) were published in journals with a high impact factor (top quarter). The IPD meta-analyses showed low compliance in using a satisfactory technique to assess the risk of bias of the included randomised contr

SUBMITTER: Wang H 

PROVIDER: S-EPMC8054226 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature