High-throughput microscopy reveals the impact of multifactorial environmental perturbations on colorectal cancer cell growth.

ABSTRACT:

Background

Colorectal cancer (CRC) mortality is principally due to metastatic disease, with the most frequent organ of metastasis being the liver. Biochemical and mechanical factors residing in the tumor microenvironment are considered to play a pivotal role in metastatic growth and response to therapy. However, it is difficult to study the tumor microenvironment systematically owing to a lack of fully controlled model systems that can be investigated in rigorous detail.

Results

We present a quantitative imaging dataset of CRC cell growth dynamics influenced by in vivo-mimicking conditions. They consist of tumor cells grown in various biochemical and biomechanical microenvironmental contexts. These contexts include varying oxygen and drug concentrations, and growth on conven

SUBMITTER: Chiang CT 

PROVIDER: S-EPMC8054261 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature