Radiomics-based assessment of idiopathic pulmonary fibrosis is associated with genetic mutations and patient survival.

ABSTRACT: Purpose: The purpose of our study was to combine differences in radiomic features extracted from lung regions in the computed tomography (CT) scans of patients diagnosed with idiopathic pulmonary fibrosis (IPF) to identify associations with genetic variations and patient survival. Approach: A database of CT scans and genomic data from 169 patients diagnosed with IPF was collected retrospectively. Six region-of-interest pairs (three per lung, positioned posteriorly, anteriorly, and laterally) were placed in each of three axial CT sections for each patient. Thirty-one features were used in logistic regression to classify patients' genetic mutation status; classification performance was evaluated through the area under the receiver operating characteristic (ROC) curve [average a

SUBMITTER: Budzikowski JD 

PROVIDER: S-EPMC8054271 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature