Severe sleep disturbance is associated with executive function impairment in patients with first-episode, treatment-naive major depressive disorders.

ABSTRACT:

Background

Sleep disturbance and executive function impairment are common in patients with major depressive disorder (MDD), though the relationship between the two remains unclear. We investigated this association in first-episode, treatment-naïve patients with MDD.

Methods

We analyzed data from 242 patients with MDD. We divided the patients into 2 groups based on sleep disturbance severity and compared the executive function odds ratios between the groups.

Results

A total of 121 pairs of patients were matched (age 39.4 ± 10.1, 70.2% female). After propensity score matching, the odds ratios for cognitive impairment in patients with MDD and severe sleep disturbance were 1.922 (1.068-3.459, P = 0.029, q = 0.044) in executive functioning; 2.023 (1.211-3.379, P = 0.007, q

SUBMITTER: Cui F 

PROVIDER: S-EPMC8054425 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature