4R-cembranoid confers neuroprotection against LPS-induced hippocampal inflammation in mice.

ABSTRACT:

Background

Chronic brain inflammation has been implicated in the pathogenesis of various neurodegenerative diseases and disorders. For example, overexpression of pro-inflammatory cytokines has been associated with impairments in hippocampal-dependent memory. Lipopolysaccharide (LPS) injection is a widely used model to explore the pathobiology of inflammation. LPS injection into mice causes systemic inflammation, neuronal damage, and poor memory outcomes if the inflammation is not controlled. Activation of the alpha-7 nicotinic receptor (α7) plays an anti-inflammatory role in the brain through vagal efferent nerve signaling. 4R-cembranoid (4R) is a natural compound that crosses the blood-brain barrier, induces neuronal survival, and has been shown to modulate the activity of nicotin

SUBMITTER: Rojas-Colon LA 

PROVIDER: S-EPMC8054431 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature