Facile fabrication of multi-pocket nanoparticles with stepwise size transition for promoting deep penetration and tumor targeting.

ABSTRACT:

Background

Nanocarriers-derived antitumor therapeutics are often associated with issues of limited tumor penetration and dissatisfactory antitumor efficacies. Some multistage delivery systems have been constructed to address these issues, but they are often accompanied with complicated manufacture processes and undesirable biocompatibility, which hinder their further application in clinical practices. Herein, a novel dual-responsive multi-pocket nanoparticle was conveniently constructed through self-assembly and cross-linking of amphiphilic methoxypolyethylene glycol-lipoic acid (mPEG-LA) conjugates to enhance tumor penetration and antitumor efficacy.

Results

The multi-pocket nanoparticles (MPNs) had a relatively large size of ~ 170 nm at physiological pH which results in pr

SUBMITTER: Hou X 

PROVIDER: S-EPMC8054436 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature