Metabolites Associated with Early Cognitive Changes Implicated in Alzheimer's Disease.

ABSTRACT:

Background

Understanding metabolic mechanisms associated with cognitive changes preceding an Alzheimer's disease (AD) diagnosis could advance our understanding of AD progression and inform preventive methods.

Objective

We investigated the metabolomics of the early changes in executive function and delayed recall, the earliest aspects of cognitive function to change in the course of AD development, in order to better understand mechanisms that could contribute to early stages and progression of this disease.

Methods

This investigation used longitudinal plasma samples from the Wisconsin Registry for Alzheimer's Prevention (WRAP), a cohort of participants who were dementia free at enrollment and enriched with a parental history of AD. Metabolomic profiles were quantified

SUBMITTER: Darst BF 

PROVIDER: S-EPMC8054536 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature