Long-Term Blood Pressure Variability Across the Clinical and Biomarker Spectrum of Alzheimer's Disease.

ABSTRACT:

Background

Elevated blood pressure is linked to cognitive impairment and Alzheimer's disease (AD) biomarker abnormality. However, blood pressure levels vary over time. Less is known about the role of long-term blood pressure variability in cognitive impairment and AD pathophysiology.

Objective

Determine whether long-term blood pressure variability is elevated across the clinical and biomarker spectrum of AD.

Methods

Alzheimer's Disease Neuroimaging Initiative participants (cognitively normal, mild cognitive impairment, AD [n = 1,421]) underwent baseline exam, including blood pressure measurement at 0, 6, and 12 months. A subset (n = 318) underwent baseline lumbar puncture to determine cerebrospinal fluid amyloid-β and phosphorylated tau levels. Clinical groups and bio

SUBMITTER: Sible IJ 

PROVIDER: S-EPMC8054661 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature