Binding of the synaptic vesicle radiotracer [¹¹C]UCB-J is unchanged during functional brain activation using a visual stimulation task.

ABSTRACT: The positron emission tomography radioligand [¹¹C]UCB-J binds to synaptic vesicle glycoprotein 2 A (SV2A), a regulator of vesicle release. Increased neuronal firing could potentially affect tracer concentrations if binding site availability is altered during vesicle exocytosis. This study assessed whether physiological brain activation induces changes in [¹¹C]UCB-J tissue influx (K₁), volume of distribution (V_T), or binding potential (BP_ND). Healthy volunteers (n = 7) underwent 60-min [¹¹C]UCB-J PET scans at baseline and during intermittent presentation of 8-Hz checkerboard visual stimulation. Sensitivity to intermittent changes in kinetic parameters was assessed in simulations, and visual stimula

SUBMITTER: Smart K 

PROVIDER: S-EPMC8054713 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature