Differential contribution of excitatory and inhibitory neurons in shaping neurovascular coupling in different epileptic neural states.

ABSTRACT: Understanding the neurovascular coupling (NVC) underlying hemodynamic changes in epilepsy is crucial to properly interpreting functional brain imaging signals associated with epileptic events. However, how excitatory and inhibitory neurons affect vascular responses in different epileptic states remains unknown. We conducted real-time in vivo measurements of cerebral blood flow (CBF), vessel diameter, and excitatory and inhibitory neuronal calcium signals during recurrent focal seizures. During preictal states, decreases in CBF and arteriole diameter were closely related to decreased γ-band local field potential (LFP) power, which was linked to relatively elevated excitatory and reduced inhibitory neuronal activity levels. Notably, this preictal condition was followed by a strengthened icta

SUBMITTER: Lim HK 

PROVIDER: S-EPMC8054729 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature