Clinical Determinants of Severe COVID-19 Disease - A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

A systematic review and meta-analysis of available studies was performed to investigate the clinical characteristics that can predict COVID-19 disease severity.

Materials and methods

Databases including PubMed, Embase, and Web of Science were searched from December 31, 2019, to May 24, 2020. Random-effects meta-analysis was used for summarizing the Pooled odds ratio (pOR) of individual clinical characteristics to describe their association with severe COVID-19 disease.

Results

A total of 3895 articles were identified, and finally, 22 studies comprising 4380 patients were included. Severe disease was more common in males than females (pOR: 1.36, 95% confidence interval [CI]: 1.08-1.70). Clinical features that were associated with significantly higher odds of

SUBMITTER: Sahu AK 

PROVIDER: S-EPMC8054797 | biostudies-literature | 2021 Jan-Mar

REPOSITORIES: biostudies-literature