Quantifying Duration of Proteinuria Remission and Association with Clinical Outcome in IgA Nephropathy.

ABSTRACT:

Background

On the basis of findings of observational studies and a meta-analysis, proteinuria reduction has been proposed as a surrogate outcome in IgA nephropathy. How long a reduction in proteinuria needs to be maintained to mitigate the long-term risk of disease progression is unknown.

Methods

In this retrospective multiethnic cohort of adult patients with IgA nephropathy, we defined proteinuria remission as a ≥25% reduction in proteinuria from the peak value after biopsy, and an absolute reduction in proteinuria to <1 g/d. The exposure of interest was the total duration of first remission, treated as a time-varying covariate using longitudinal proteinuria measurements. We used time-dependent Cox proportional hazards regression models to quantify the association between t

SUBMITTER: Canney M 

PROVIDER: S-EPMC8054888 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature