Association of Cardiovascular Risk Factors with Cerebral Perfusion in Whites and African Americans.

ABSTRACT:

Background

Midlife cardiovascular risk factors increase risk for Alzheimer's disease (AD). Despite disproportionately high cardiovascular disease and dementia rates, African Americans are under-represented in studies of AD risk and research-based guidance on targeting vascular risk factors is lacking.

Objective

This study investigated relationships between specific cardiovascular risk factors and cerebral perfusion in White and African American adults enriched for AD risk.

Methods

Participants included 397 cognitively unimpaired White (n = 330) and African American (n = 67) adults enrolled in the Wisconsin Alzheimer's Disease Research Center who underwent pseudo-continuous arterial spin labeling MRI. Multiple linear regression models examined independent relationships

SUBMITTER: Clark LR 

PROVIDER: S-EPMC8054937 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature