Progress toward improving outcomes in patients with cholangiocarcinoma.

ABSTRACT:

Purpose of review

To provide an update on latest advances in treatment of cholangiocarcinoma.

Recent findings

Incidence of cholangiocarcinoma has been increasing over the past decade. A better understanding of the genetic landscape of cholangiocarcinoma and its risk factors resulted in earlier diagnosis and treatment option expansion to targeted therapy with FGFR inhibitors, and liver transplantation for early perihilar cholangiocarcinoma and early intrahepatic cholangiocarcinoma. IDH1/2 inhibition for intrahepatic cholangiocarcinoma is an emerging targeted therapy approach. Data supports benefits of adjuvant therapy for a subset of patients undergoing surgical resection. Approaches combining different treatment modalities such as chemotherapy, surgery, radiation therapy app

SUBMITTER: Kawasaki H 

PROVIDER: S-EPMC8054970 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature