Computational modelling of perivascular-niche dynamics for the optimization of treatment schedules for glioblastoma.

ABSTRACT: Glioblastoma stem-like cells dynamically transition between a chemoradiation-resistant state and a chemoradiation-sensitive state. However, physical barriers in the tumour microenvironment restrict the delivery of chemotherapy to tumour compartments that are distant from blood vessels. Here, we show that a massively parallel computational model of the spatiotemporal dynamics of the perivascular niche that incorporates glioblastoma stem-like cells and differentiated tumour cells as well as relevant tissue-level phenomena can be used to optimize the administration schedules of concurrent radiation and temozolomide-the standard-of-care treatment for glioblastoma. In mice with platelet-derived growth factor (PDGF)-driven glioblastoma, the model-optimized treatment schedule increased the surviv

SUBMITTER: Randles A 

PROVIDER: S-EPMC8054983 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature