Systematic review and meta-analysis of breast cancer brain metastasis and primary tumor receptor expression discordance.

ABSTRACT:

Background

Change in hormone receptor (estrogen [ER] and progesterone [PR]) and/or human epidermal growth factor receptor type 2 (HER2) status during the evolutionary course of metastatic breast cancer and the effect of tumor classification subtype switching remain understudied and underappreciated in brain metastasis patients.

Methods

Using preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines, a systematic review of series published prior to April 2020 obtained from the Medline database of biopsied or resected breast cancer brain metastasis (BCBM) was performed. Weighted random effects models were used to calculate pooled estimates.

Results

15 full-text articles were included with receptor expression analyses on 1373 patients who und

SUBMITTER: Kotecha R 

PROVIDER: S-EPMC8055057 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature