Can synthetic data be a proxy for real clinical trial data? A validation study.

ABSTRACT:

Objectives

There are increasing requirements to make research data, especially clinical trial data, more broadly available for secondary analyses. However, data availability remains a challenge due to complex privacy requirements. This challenge can potentially be addressed using synthetic data.

Setting

Replication of a published stage III colon cancer trial secondary analysis using synthetic data generated by a machine learning method.

Participants

There were 1543 patients in the control arm that were included in our analysis.

Primary and secondary outcome measures

Analyses from a study published on the real dataset were replicated on synthetic data to investigate the relationship between bowel obstruction and event-free survival. Information theoretic metrics

SUBMITTER: Azizi Z 

PROVIDER: S-EPMC8055130 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature