Blood Pressure Effects of Sodium Reduction: Dose-Response Meta-Analysis of Experimental Studies.

ABSTRACT:

Background

The relationship between dietary sodium intake and blood pressure (BP) has been tested in clinical trials and nonexperimental human studies, indicating a direct association. The exact shape of the dose-response relationship has been difficult to assess in clinical trials because of the lack of random-effects dose-response statistical models that can include 2-arm comparisons.

Methods

After performing a comprehensive literature search for experimental studies that investigated the BP effects of changes in dietary sodium intake, we conducted a dose-response meta-analysis using the new 1-stage cubic spline mixed-effects model. We included trials with at least 4 weeks of follow-up; 24-hour urinary sodium excretion measurements; sodium manipulation through dietary chan

SUBMITTER: Filippini T 

PROVIDER: S-EPMC8055199 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature