Association of CSF Biomarkers With Hippocampal-Dependent Memory in Preclinical Alzheimer Disease.

ABSTRACT:

Objective

To determine whether memory tasks with demonstrated sensitivity to hippocampal function can detect variance related to preclinical Alzheimer disease (AD) biomarkers, we examined associations between performance in 3 memory tasks and CSF β-amyloid (Aβ)₄₂/Aβ₄₀ and phosopho-tau₁₈₁ (p-tau₁₈₁) in cognitively unimpaired older adults (CU).

Methods

CU enrolled in the Stanford Aging and Memory Study (n = 153; age 68.78 ± 5.81 years; 94 female) completed a lumbar puncture and memory assessments. CSF Aβ₄₂, Aβ₄₀, and p-tau₁₈₁ were measured with the automated Lumipulse G system in a single-batch analysis. Episodic memory was assayed using a standardized delayed recall composite, paired associate (word-

SUBMITTER: Trelle AN 

PROVIDER: S-EPMC8055319 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature