Macrophage Polarization in the Skin Lesion Caused by Neotropical Species of Leishmania sp.

ABSTRACT: Macrophages play important roles in the innate and acquired immune responses against Leishmania parasites. Depending on the subset and activation status, macrophages may eliminate intracellular parasites; however, these host cells also can offer a safe environment for Leishmania replication. In this sense, the fate of the parasite may be influenced by the phenotype of the infected macrophage, linked to the subtype of classically activated (M1) or alternatively activated (M2) macrophages. In the present study, M1 and M2 macrophage subsets were analyzed by double-staining immunohistochemistry in skin biopsies from patients with American cutaneous leishmaniasis (ACL) caused by L. (L.) amazonensis, L. (V.) braziliensis, L. (V.</

SUBMITTER: Sandoval Pacheco CM 

PROVIDER: S-EPMC8055412 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature