Gene-environment correlations and causal effects of childhood maltreatment on physical and mental health: a genetically informed approach.

ABSTRACT:

Background

Childhood maltreatment is associated with poor mental and physical health. However, the mechanisms of gene-environment correlations and the potential causal effects of childhood maltreatment on health are unknown. Using genetics, we aimed to delineate the sources of gene-environment correlation for childhood maltreatment and the causal relationship between childhood maltreatment and health.

Methods

We did a genome-wide association study meta-analysis of childhood maltreatment using data from the UK Biobank (n=143 473), Psychiatric Genomics Consortium (n=26 290), Avon Longitudinal Study of Parents and Children (n=8346), Adolescent Brain Cognitive Development Study (n=5400), and Generation R (n=1905). We included individuals who had phenotypic and genetic data avail

SUBMITTER: Warrier V 

PROVIDER: S-EPMC8055541 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature