Glucocorticoids dexamethasone and prednisolone suppress fibroblast growth factor 23 (FGF23).

ABSTRACT: Fibroblast growth factor 23 (FGF23) is a hormone mainly secreted by bone cells. Its most prominent effects are the regulation of renal phosphate reabsorption and calcitriol (active vitamin D, 1,25(OH)₂D₃) formation, effects dependent on its co-receptor αKlotho. Besides these actions, further paracrine and endocrine effects exist. The production of FGF23 is regulated by 1,25(OH)₂D₃, parathyroid hormone, dietary phosphate intake, iron status, as well as inflammation. Glucocorticoids are hormones with anti-inflammatory properties and are, therefore, widely used for acute and chronic inflammatory diseases, autoimmune disorders, and malignancies. The present study explored whether glucocorticoids influence the production of FGF23 in vitro as well as i

SUBMITTER: Feger M 

PROVIDER: S-EPMC8055636 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature