Ontology highlight
ABSTRACT:
SUBMITTER: Wong F
PROVIDER: S-EPMC8055701 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Wong Felix F Stokes Jonathan M JM Cervantes Bernardo B Penkov Sider S Friedrichs Jens J Renner Lars D LD Collins James J JJ
Nature communications 20210419 1
Bactericidal antibiotics kill bacteria by perturbing various cellular targets and processes. Disruption of the primary antibiotic-binding partner induces a cascade of molecular events, leading to overproduction of reactive metabolic by-products. It remains unclear, however, how these molecular events contribute to bacterial cell death. Here, we take a single-cell physical biology approach to probe antibiotic function. We show that aminoglycosides and fluoroquinolones induce cytoplasmic condensat ...[more]