Phosphate Brain Energy Metabolism and Cognition in Alzheimer's Disease: A Spectroscopy Study Using Whole-Brain Volume-Coil ³¹Phosphorus Magnetic Resonance Spectroscopy at 7Tesla.

ABSTRACT:

Introduction

Mitochondrial dysfunction is a neurometabolic hallmark signaling abnormal brain energy metabolism (BEM) targeted as a potential early marker of Alzheimer's disease (AD). Advanced imaging technologies, such as ³¹phosphorus magnetic resonance spectroscopy (³¹P MRS) at ultra-high-field (UHF) magnetic strength 7T, provide sensitive phosphate-BEM (p-BEM) data with precision. The study's first goal was to develop a methodology to measure phosphate energy and membrane metabolites simultaneously across the whole-brain using volume-coil ³¹P MRS at 7T in three groups-cognitively normal (CN), amnestic mild cognitive impairment (aMCI), and AD. The second aim investigated whether p-BEM markers in the four brain regions-frontal, temporal, parietal, a

SUBMITTER: Das N 

PROVIDER: S-EPMC8055842 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature