Blood tryptase and thymic stromal lymphopoietin levels predict the risk of exacerbation in severe asthma.

ABSTRACT: Some patients with severe asthma experience exacerbations despite receiving multiple therapy. The risk of exacerbation and heterogeneous response to treatment may be associated with specific inflammatory molecules that are responsive or resistant to corticosteroids. We aimed to identify the independent factors predictive for the future risk of exacerbation in patients with severe asthma. In this multi-center prospective observational study, 132 patients with severe asthma were enrolled and divided into exacerbation (n = 52) and non-exacerbation (n = 80) groups on the basis of exacerbation rate after a 1-year follow-up period. We found that previous history of severe-to-serious exacerbation, baseline blood eosinophil counts (≥ 291cells/μL), and serum tryptase (≤ 1448 pg/mL) and thrymic stro

SUBMITTER: Ko HK 

PROVIDER: S-EPMC8055991 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature