Cardiac Energetics Before, During, and After Anthracycline-Based Chemotherapy in Breast Cancer Patients Using ³¹P Magnetic Resonance Spectroscopy: A Pilot Study.

ABSTRACT: Purpose: To explore the utility of phosphorus magnetic resonance spectroscopy (³¹P MRS) in identifying anthracycline-induced cardiac toxicity in patients with breast cancer. Methods: Twenty patients with newly diagnosed breast cancer receiving anthracycline-based chemotherapy had cardiac magnetic resonance assessment of left ventricular ejection fraction (LVEF) and ³¹P MRS to determine myocardial Phosphocreatine/Adenosine Triphosphate Ratio (PCr/ATP) at three time points: pre-, mid-, and end-chemotherapy. Plasma high sensitivity cardiac troponin-I (cTn-I) tests and electrocardiograms were also performed at these same time points. Results: Phosphocreatine/Adenosine Triphosphate did not change significantly between pre- and mid-chemo (2.16 ± 0.46 vs

SUBMITTER: Macnaught G 

PROVIDER: S-EPMC8056038 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature