Multi-Omics Analysis of Brain Metastasis Outcomes Following Craniotomy.

ABSTRACT:

Background

The incidence of brain metastasis continues to increase as therapeutic strategies have improved for a number of solid tumors. The presence of brain metastasis is associated with worse prognosis but it is unclear if distinctive biomarkers can separate patients at risk for CNS related death.

Methods

We executed a single institution retrospective collection of brain metastasis from patients who were diagnosed with lung, breast, and other primary tumors. The brain metastatic samples were sent for RNA sequencing, proteomic and metabolomic analysis of brain metastasis. The primary outcome was distant brain failure after definitive therapies that included craniotomy resection and radiation to surgical bed. Novel prognostic subtypes were discovered using transcriptomic da

SUBMITTER: Su J 

PROVIDER: S-EPMC8056216 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature