Sulforaphane exposure impairs contractility and mitochondrial function in three-dimensional engineered heart tissue.

ABSTRACT: Sulforaphane (SFN) is a phytochemical compound extracted from cruciferous plants, like broccoli or cauliflower. Its isothiocyanate group renders SFN reactive, thus allowing post-translational modification of cellular proteins to regulate their function with the potential for biological and therapeutic actions. SFN and stabilized variants recently received regulatory approval for clinical studies in humans for the treatment of neurological disorders and cancer. Potential unwanted side effects of SFN on heart function have not been investigated yet. The present study characterizes the impact of SFN on cardiomyocyte contractile function in cardiac preparations from neonatal rat, adult mouse and human induced-pluripotent stem cell-derived cardiomyocytes. This revealed a SFN-mediated negative i

SUBMITTER: Rhoden A 

PROVIDER: S-EPMC8056268 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature