Association of Oral Corticosteroid Bursts With Severe Adverse Events in Children.

ABSTRACT:

Importance

The adverse effects from the long-term use of oral corticosteroids are known, but, to our knowledge, few studies have reported the risk of corticosteroid bursts, particularly among children.

Objective

To quantify the associations of corticosteroid bursts with severe adverse events, including gastrointestinal (GI) bleeding, sepsis, pneumonia, and glaucoma, in children.

Design, setting, and participants

This study used data derived from the National Health Insurance Research Database in Taiwan from January 1, 2013, to December 31, 2017, on children younger than 18 years of age and used a self-controlled case series design. Data were analyzed from January 1 to July 30, 2020.

Exposure

Oral corticosteroid bursts (defined as oral corticosteroid use for ≤14

SUBMITTER: Yao TC 

PROVIDER: S-EPMC8056312 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature