Association of Epidural Labor Analgesia With Offspring Risk of Autism Spectrum Disorders.

ABSTRACT:

Importance

Epidural labor analgesia (ELA) has been associated with an increased offspring risk of autism spectrum disorder (ASD). Whether this finding may be explained by residual confounding remains unclear.

Objective

To assess the association between ELA and offspring risk of ASD.

Design, setting, and participants

Longitudinal cohort study of vaginal deliveries of singleton live infants born from 2005 to 2016 from a population-based data set linking information from health care databases in Manitoba, Canada; offspring were followed from birth until 2019 or censored by death or emigration. Data were analyzed from October 19, 2020, to January 22, 2021.

Exposures

Epidural labor analgesia.

Main outcomes and measures

At least 1 inpatient or outpatient diagn

SUBMITTER: Wall-Wieler E 

PROVIDER: S-EPMC8056314 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature