Inhibition of DKC1 induces telomere-related senescence and apoptosis in lung adenocarcinoma.

ABSTRACT:

Background

Lung cancer is one of the most widely spread cancers in the world and half of the non-small cell lung cancers are lung adenocarcinoma (LUAD). Although there were several drugs been approved for LUAD therapy, a large portion of LUAD still cannot be effectively treated due to lack of available therapeutic targets. Here, we investigated the oncogenic roles of DKC1 in LUAD and its potential mechanism and explored the possibility of targeting DKC1 for LUAD therapy.

Methods

The Gene Expression Omnibus (GEO) and The Cancer Genome Atlas Program (TCGA) databases were used to examine the DKC1 transcript levels. Gene expression with clinical information from tissue microarray of LUAD were analyzed for associations between DKC1 expression and LUAD prognosis. In addition, loss

SUBMITTER: Kan G 

PROVIDER: S-EPMC8056518 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature